International Conference on Statistics, Mathematics, Teaching, and Research (ICSMTR) 2021 is the 4th ICSMTR and the biennial event organized by the Department of Statistics and the Department of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Negeri Makassar. The conference provides a forum for discussion on improving the quality of research and publication by promoting cutting-edge methods of Statistics, Mathematics, and Sciences. The conference program includes keynote presentation, workshops, invited speakers, and parallel presentation sessions. This conference will be held online on 9-10 October 2021. Lecturers, researchers, practitioners, teachers, students are kindly invited to participate and submit their papers. The submitted papers comprise original unpublished material.